Four hip women get ready for Friday night in LA: they dress, talk about sex, and hit a bar before meeting four men at a rave. The men prepare by talking about sex and drinking. Rick and Jean, two attorneys, have set up the evening, connect at the club, and have a good time. The pairings of Shawn, Trent, Whitney and Emma are more serendipitous. But it's Mike and Sara's night that has serious repercussions: he's an NFL player, loud, swaggering; she's a party animal who drinks a lot early that evening. At 4 AM, she appears at Jean's, disheveled and bruised, saying Mike raped her. Arrested, he says he's innocent, and in flashbacks we see both sides of the story.

George Bynum, a patient of Manhattan psychiatrist Dr. Sam Rice, is brutally murdered. Soon afterward, Dr. Rice is visited by Bynum's co-worker and mistress Brooke Reynolds and by the investigating officer Detective Vitucci. As Dr. Rice reviews the case notes on his sessions with Bynum, he starts his own investigation. At the same time, he finds himself falling for enigmatic blonde Brooke, despite her increasingly suspicious behavior. The closer Rice comes to the truth, the more he puts his own life in danger...